Anti-influenza virus agents: synthesis and mode of action

Med Res Rev. 2008 Jan;28(1):1-38. doi: 10.1002/med.20096.


Annual epidemics of influenza virus infection are responsible for considerable morbidity and mortality, and pandemics are much more devastating. Considerable knowledge of viral infectivity and replication has been acquired, but many details still have to be elucidated and the virus remains a challenging target for drug design and development. This review provides an overview of the antiviral drugs targeting the influenza viral replicative cycle. Included are a brief description of their chemical syntheses and biological activities. For other reviews, see References1-9.

Publication types

  • Review

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Humans
  • Orthomyxoviridae / drug effects*
  • Orthomyxoviridae / physiology
  • Virus Replication / drug effects
  • Virus Replication / physiology


  • Antiviral Agents