Treatment of toxic epidermal necrolysis in a pediatric patient with a nanocrystalline silver dressing

J Pediatr Surg. 2006 Dec;41(12):e9-12. doi: 10.1016/j.jpedsurg.2006.08.043.


Background/purpose: To report a case of toxic epidermal necrolysis (TEN) involving 90% body surface area, successfully treated with a nanocrystalline silver dressing (Acticoat, Smith & Nephew, Largo, FL).

Methods: A review of the hospital and acute wound center patient records and the recent English medical literature regarding TEN and nanocrystalline silver dressing.

Results: We found only 1 report of TEN treated with a nanocrystalline silver dressing. The nanocrystalline silver dressing was both effective in preventing wound infection and convenient for treating our patient with TEN.

Conclusion: The use of nanocrystalline silver dressing should be considered for the treatment of TEN.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bandages
  • Female
  • Humans
  • Metal Nanoparticles
  • Occlusive Dressings
  • Polyesters / therapeutic use*
  • Polyethylenes / therapeutic use*
  • Stevens-Johnson Syndrome / therapy*
  • Wound Healing / drug effects*


  • Acticoat
  • Polyesters
  • Polyethylenes