Pin1 flips Alzheimer's switch

ACS Chem Biol. 2006 May 23;1(4):214-6. doi: 10.1021/cb600171g.

Abstract

The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for Pin1 regulation of APP processing is also proposed.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / prevention & control
  • Amyloid beta-Protein Precursor / chemistry
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Humans
  • Models, Biological
  • NIMA-Interacting Peptidylprolyl Isomerase
  • Peptidylprolyl Isomerase / chemistry*
  • Peptidylprolyl Isomerase / metabolism
  • Peptidylprolyl Isomerase / physiology*

Substances

  • Amyloid beta-Protein Precursor
  • NIMA-Interacting Peptidylprolyl Isomerase
  • PIN1 protein, human
  • Peptidylprolyl Isomerase