Abstract
The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for Pin1 regulation of APP processing is also proposed.
MeSH terms
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Alzheimer Disease / metabolism*
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Alzheimer Disease / prevention & control
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Amyloid beta-Protein Precursor / chemistry
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Amyloid beta-Protein Precursor / metabolism*
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Animals
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Humans
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Models, Biological
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NIMA-Interacting Peptidylprolyl Isomerase
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Peptidylprolyl Isomerase / chemistry*
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Peptidylprolyl Isomerase / metabolism
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Peptidylprolyl Isomerase / physiology*
Substances
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Amyloid beta-Protein Precursor
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NIMA-Interacting Peptidylprolyl Isomerase
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PIN1 protein, human
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Peptidylprolyl Isomerase