Abstract
Two recent papers attempt to solve both the tumor selectivity and the in vivo tumor accumulation profiles seen with some Hsp90 inhibitors. They spotlight the higher affinity of ansamycins' hydroquinone over the quinone form for Hsp90 and further discuss its possible contribution to ansamycins' tumor selectivity.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / classification
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Antineoplastic Agents / pharmacology*
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HSP90 Heat-Shock Proteins / antagonists & inhibitors*
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HSP90 Heat-Shock Proteins / physiology*
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Humans
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Neoplasms / drug therapy*
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Neoplasms / metabolism*
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Neoplasms / pathology
Substances
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Antineoplastic Agents
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HSP90 Heat-Shock Proteins