RNA Recognition: Towards Identifying Determinants of Specificity

Trends Biochem Sci. 1991 Jun;16(6):214-20. doi: 10.1016/0968-0004(91)90088-d.

Abstract

Members of a family of proteins containing a conserved approximately 80-amino acid RNA recognition motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in combination with sequence alignments, indicate the structural context of both conserved and non-conserved elements in the motif. These analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.

MeSH terms

  • Amino Acid Sequence
  • Carrier Proteins / metabolism*
  • RNA / metabolism*
  • RNA-Binding Proteins

Substances

  • Carrier Proteins
  • RNA-Binding Proteins
  • RNA