15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size)

Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):135-46. doi: 10.1016/j.prostaglandins.2006.05.022. Epub 2006 Jul 7.


15-Lipoxygenase 2 (15-LOX2) is the major mammalian lipoxygenase expressed in normal human adult prostate and its expression is decreased or lost in high-grade prostate intraepithelial neoplasia (HGPIN) and prostate cancer (PCa). Our recent work has demonstrated that (1) 15-LOX2 has multiple alternatively spliced isoforms and is a negative cell-cycle regulator in normal human prostate (NHP) epithelial cells; (2) 15-LOX2 in NHP cells is positively regulated by Sp1 and negatively regulated by Sp3; (3) 15-LOX2 in NHP cells may be partially involved in cell differentiation; (4) 15-LOX2 is cell-autonomously upregulated in cultured NHP cells and its induction is associated with NHP cell senescence; and (5) 15-LOX2 is a functional prostate tumor suppressor. Here we summarize these new findings to provide a concise view of the potential biological functions of 15-LOX2 in NHP cells and of its deregulation in PCa development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adult
  • Alternative Splicing
  • Arachidonate 15-Lipoxygenase / genetics
  • Arachidonate 15-Lipoxygenase / physiology*
  • Cadherins / physiology
  • Cell Cycle Proteins / physiology*
  • Cell Differentiation
  • Cell Enlargement
  • Cellular Senescence
  • Epithelial Cells / cytology*
  • Gene Expression
  • Humans
  • Hydroxyeicosatetraenoic Acids / physiology
  • Male
  • Prostate / cytology*
  • Prostatic Neoplasms / physiopathology
  • Receptors, Androgen / physiology
  • Sp1 Transcription Factor / physiology
  • Sp3 Transcription Factor / physiology
  • Tumor Suppressor Proteins / physiology*


  • Cadherins
  • Cell Cycle Proteins
  • Hydroxyeicosatetraenoic Acids
  • Receptors, Androgen
  • SP3 protein, human
  • Sp1 Transcription Factor
  • Tumor Suppressor Proteins
  • Sp3 Transcription Factor
  • 15-hydroxy-5,8,11,13-eicosatetraenoic acid
  • ALOX15B protein, human
  • Arachidonate 15-Lipoxygenase