Abstract
A major role of TNF in pulmonary fibrosis is supported by the following evidences obtained from pulmonary fibrosis induced in mice by bleomycin or silica particles; 1) these diseases are associated with a marked and lasting increase of the TNF mRNA within the lung, 2) they can be prevented by a treatment with anti TNF antibody or aggravated by a perfusion of mouse recombinant TNF, 3) an infusion of TNF-alpha can reproduce the alterations observed during pulmonary fibrosis such as growth of fibroblasts, collagen deposition, cell necrosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies / pharmacology
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Bleomycin / toxicity
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Collagen / biosynthesis
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Lipopolysaccharides / toxicity
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Lung / chemistry
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Mice
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Pulmonary Fibrosis / etiology
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Pulmonary Fibrosis / physiopathology*
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RNA, Messenger / analysis
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Recombinant Proteins / pharmacology
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Silicosis / complications
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Tumor Necrosis Factor-alpha / biosynthesis
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Tumor Necrosis Factor-alpha / immunology
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Tumor Necrosis Factor-alpha / pharmacology
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Tumor Necrosis Factor-alpha / physiology*
Substances
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Antibodies
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Lipopolysaccharides
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RNA, Messenger
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Recombinant Proteins
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Tumor Necrosis Factor-alpha
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Bleomycin
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Collagen