Is "tumor necrosis factor" the major effector of pulmonary fibrosis?

Eur Cytokine Netw. 1990 Oct-Nov;1(4):257-8.

Abstract

A major role of TNF in pulmonary fibrosis is supported by the following evidences obtained from pulmonary fibrosis induced in mice by bleomycin or silica particles; 1) these diseases are associated with a marked and lasting increase of the TNF mRNA within the lung, 2) they can be prevented by a treatment with anti TNF antibody or aggravated by a perfusion of mouse recombinant TNF, 3) an infusion of TNF-alpha can reproduce the alterations observed during pulmonary fibrosis such as growth of fibroblasts, collagen deposition, cell necrosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / pharmacology
  • Bleomycin / toxicity
  • Collagen / biosynthesis
  • Lipopolysaccharides / toxicity
  • Lung / chemistry
  • Mice
  • Pulmonary Fibrosis / etiology
  • Pulmonary Fibrosis / physiopathology*
  • RNA, Messenger / analysis
  • Recombinant Proteins / pharmacology
  • Silicosis / complications
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Tumor Necrosis Factor-alpha / immunology
  • Tumor Necrosis Factor-alpha / pharmacology
  • Tumor Necrosis Factor-alpha / physiology*

Substances

  • Antibodies
  • Lipopolysaccharides
  • RNA, Messenger
  • Recombinant Proteins
  • Tumor Necrosis Factor-alpha
  • Bleomycin
  • Collagen