Hyperserotonemia in adults with autistic disorder

J Autism Dev Disord. 2007 Nov;37(10):1934-40. doi: 10.1007/s10803-006-0324-6. Epub 2006 Dec 13.


Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 +/- 37.4 ng/microL) was significantly higher than the control sample (59.2 +/- 16.2 ng/microL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Autistic Disorder / blood*
  • Autistic Disorder / diagnosis
  • Blood Platelets / metabolism
  • Female
  • Humans
  • Intellectual Disability / blood
  • Intellectual Disability / diagnosis
  • Language Development Disorders / blood
  • Male
  • Reference Values
  • Serotonin / blood*
  • Speech Disorders / blood
  • Speech Disorders / diagnosis
  • Statistics as Topic
  • Verbal Behavior / physiology


  • Serotonin