Abstract
A convergent and highly stereocontrolled synthesis of amphidinolide E (1) has been accomplished. The synthesis features a highly diastereoselective (>20:1) BF3.Et2O promoted [3+2] annulation reaction between aldehyde 3 and allylsilane 4 to afford substituted tetrahydrofuran 2.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aldehydes / chemical synthesis
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Aldehydes / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Esterification
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Molecular Structure
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Silanes / chemical synthesis
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Silanes / chemistry
Substances
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Aldehydes
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Bridged Bicyclo Compounds, Heterocyclic
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Silanes
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amphidinolide E