Bone and prostate cancer cell interactions in metastatic prostate cancer

BJU Int. 2007 Apr;99(4):735-42. doi: 10.1111/j.1464-410X.2006.06670.x. Epub 2006 Dec 13.


The interplay in prostate cancer bone metastases between the 'seed' (the prostate cancer cells) and the 'soil' (the bone microenvironment) has been increasingly recognized as integral to the remarkable tropism for bone shown by prostate cancer. Increasing research into this area is elucidating the mechanisms involved in this complex 'cross-talk'. Recent developments, including the use of bisphosphonates in metastatic disease, highlight the important role of bone cells in the development and progression of metastatic prostate cancer. We review the current reports emphasising these possible mechanisms and indicating possible factors for future treatment directions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology
  • Bone Density / physiology
  • Bone Neoplasms / metabolism*
  • Bone Neoplasms / secondary
  • Bone Remodeling / physiology
  • Cell Communication / physiology*
  • Hormones / physiology
  • Humans
  • Male
  • Neoplasm Proteins / metabolism
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology


  • Hormones
  • Neoplasm Proteins