Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats

Int J Biol Macromol. 2007 Apr 10;40(5):461-5. doi: 10.1016/j.ijbiomac.2006.11.002. Epub 2006 Nov 17.


Fruit from Lycium barbarum L. in the family Solanaceae is well-known in traditional Chinese herbal medicine. Lycium barbarum polysaccharides (LBP) have been identified as one of the active ingredients responsible for its biological activities. We isolated polysaccharides from dried Lycium barbarum fruits by boiling water extraction. In the study, 50 animals were divided into two groups: a nondiabetic control (n=10) and a diabetic group (n=40). Diabetes was induced by a single injection of streptozotocin (50mg/kg BW; Sigma, USA) freshly dissolved in a 0.1 mol/L citrate buffer (pH 4.5) into the intraperitonium. The normal control rats and the untreated diabetic control rats were only injected with the citrate buffer. Treated diabetic rats were administrated with LBP in drinking water through oral gavage for 30 days. At the end of experiment, oxidative indice in blood, liver and kidney of all groups were examined. The results show that administration of LBP can restore abnormal oxidative indice near normal levels. Therefore, we may assume that LBP is effective in the protection of liver and kidney tissue from the damage of STZ-induced diabetic rats and that the LBP may be of use as a antihyperglycemia agent.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Body Weight / drug effects
  • Diabetes Mellitus, Experimental
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / pharmacology*
  • Insulin / blood
  • Kidney / drug effects
  • Kidney / metabolism
  • Liver / drug effects
  • Liver / metabolism
  • Malondialdehyde / metabolism
  • Oxidative Stress / drug effects*
  • Rats
  • Rats, Wistar
  • Streptozocin / toxicity*
  • Superoxide Dismutase / metabolism


  • Blood Glucose
  • Drugs, Chinese Herbal
  • Insulin
  • lycium barbarum polysaccharide
  • Malondialdehyde
  • Streptozocin
  • Superoxide Dismutase