Overcoming inhibition of antibody responses to a malaria recombinant vaccinia virus caused by prior exposure to wild type virus

Vaccine. 1991 Jul;9(7):470-2. doi: 10.1016/0264-410x(91)90030-a.

Abstract

Pre-injection of mice with vaccinia virus inhibited the subsequent antibody response to a recombinant polypeptide expressed by vaccinia virus. The inhibition was overcome following additional challenges with recombinant vaccinia virus. This suggests that a potential disadvantage in vaccinia-immune individuals can be circumvented and may be outweighed by the advantages of the vector.

MeSH terms

  • Animals
  • Antibodies, Protozoan / biosynthesis*
  • Antibodies, Viral / biosynthesis
  • Antigens, Protozoan / immunology
  • Epitopes / immunology
  • Immunization
  • Kinetics
  • Mice
  • Mice, Inbred BALB C
  • Plasmodium falciparum / immunology*
  • Protozoan Vaccines / immunology*
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / immunology*
  • Vaccinia virus / immunology*

Substances

  • Antibodies, Protozoan
  • Antibodies, Viral
  • Antigens, Protozoan
  • Epitopes
  • Protozoan Vaccines
  • Vaccines, Synthetic