Alkyl, unsaturated, (hetero)aryl, and N-protected alpha-amino ketones by acylation of organometallic reagents

Alan R Katritzky; Khanh N B Le; Levan Khelashvili; Prabhu P Mohapatra

doi:10.1021/jo0614801

Alkyl, unsaturated, (hetero)aryl, and N-protected alpha-amino ketones by acylation of organometallic reagents

J Org Chem. 2006 Dec 22;71(26):9861-4. doi: 10.1021/jo0614801.

Authors

Alan R Katritzky¹, Khanh N B Le, Levan Khelashvili, Prabhu P Mohapatra

Affiliation

¹ Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu

PMID: 17168609
DOI: 10.1021/jo0614801

Abstract

Stable and easily accessible N-acylbenzotriazoles, derived from a variety of aliphatic, unsaturated, (hetero)aromatic, and N-protected alpha-amino carboxylic acids, were reacted with Grignard and heteroaryllithium reagents to afford corresponding ketones in good to excellent yields.