Carbohydrate-based scaffolds in drug discovery

Mini Rev Med Chem. 2006 Dec;6(12):1299-309. doi: 10.2174/138955706778993003.


Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.

Publication types

  • Review

MeSH terms

  • Carbohydrates / chemistry*
  • Drug Design*


  • Carbohydrates