A novel micronutrient supplement in skin aging: a randomized placebo-controlled double-blind study

J Cosmet Dermatol. 2005 Dec;4(4):277-84. doi: 10.1111/j.1473-2165.2005.00206.x.


Background: Skin aging, a combination of intrinsic and environmentally induced processes, predominantly ultraviolet (UV) light from the sun, results in characteristic tissue alterations, such as the degradation of collagen and the formation of visible fine lines and wrinkles.

Objective: To test the efficacy and safety of a novel micronutrient supplement (Estime) in skin aging.

Methods: A 4-month randomized double-blind controlled study including 40 subjects where the supplement was tested against placebo for 3 months followed by a 1-month supplement-free period for both groups to assess lasting effects. Efficacy measurements included skin surface evaluation, ultrasound measurement of sun-exposed and protected areas of the skin (back of the hand and ventral forearms, respectively), and photographic assessment.

Results: All investigated parameters showed a continuous and significant improvement in the active group during the 3 months of supplementation as compared to placebo. Photographs showed visible improvement of the overall skin appearance and reduction of fine lines. Ultrasound measurements showed an increase in dermis density of up to 78% in the active group (P < 0.0001). The final assessment after 1 month without supplementation showed no further improvements, but a slight decrease was observed in most improved parameters. No treatment-related side effects were reported.

Conclusion: The study demonstrated that the supplement appears to be effective and safe as an oral supplement to protect the skin and support its repair process. Recommendations are made for further evaluations.