Seizures associated with poisoning in children: tricyclic antidepressant intoxication

Pediatr Int. 2006 Dec;48(6):582-5. doi: 10.1111/j.1442-200X.2006.02276.x.

Abstract

Background: The aim of this study was to examine the characteristics of seizure due to poisoning.

Methods: This was a retrospective analysis, throughout 4 years of hospital admissions for poisoning. Data of patients with seizures due to poisoning were evaluated with respect to the causes, frequencies and complications of seizures.

Results: Among the 1561 admissions due to intoxication during the review period, seizures developed in 26 cases (1.6%). Tricyclic antidepressant overdose (n = 11, 42%) was the leading cause of seizure due to poisoning. Generalized tonic-clonic seizures were observed in 24 patients. Status epilepticus developed in six patients (23%). Mechanical ventilation was applied in 12 (46%) patients. Cardiac complications were observed in 11 (42%) patients with seizures. Two patients who had cardiac arrest due to acepromazine maleate and imipramine intoxication died.

Conclusion: One of the causes of seizures in pediatric age group is intoxication. Seizures due to intoxications may cause serious clinical conditions. Intoxications should be thought when a patient is admitted with the diagnosis of afebrile seizure even if there is no history of drug intake.

MeSH terms

  • Antidepressive Agents, Tricyclic / poisoning*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Incidence
  • Infant
  • Male
  • Medical Records
  • Retrospective Studies
  • Seizures / chemically induced*
  • Seizures / epidemiology*
  • Seizures / mortality
  • Seizures / therapy
  • Survival Analysis
  • Turkey / epidemiology

Substances

  • Antidepressive Agents, Tricyclic