Notch signalling during peripheral T-cell activation and differentiation

Nat Rev Immunol. 2007 Jan;7(1):64-75. doi: 10.1038/nri1998. Epub 2006 Dec 15.


For many years, researchers have focused on the contribution of Notch signalling to lymphoid development. Only recently have investigators begun to ask what role, if any, Notch has during the activation and differentiation of naive CD4(+) T cells in the periphery. As interest in this issue grows, it is becoming increasingly clear that the main role of Notch signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / immunology*
  • Humans
  • Lymphocyte Activation / immunology*
  • Receptors, Notch / immunology*
  • Signal Transduction / immunology*
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / immunology*


  • Receptors, Notch