The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells

Cell. 1991 Sep 20;66(6):1133-44. doi: 10.1016/0092-8674(91)90036-x.


Functional maturation of B lymphocytes correlates with expression of the B lineage-specific cell surface glycoprotein CD22. Two CD22 polypeptides have been characterized and suggested to play a role in B cell-B cell interaction as well as in B cell adhesion to monocytes. In this work we provide evidence that CD22 is directly involved in the cognate interaction between B and T cells. One of the two CD22 polypeptides, CD22 beta, interacts with a specific ligand on a subpopulation of CD4+ T cells. Our results suggest that the T cell ligand of CD22 is CD45RO, an isoform of the leukocyte common antigen class of phosphotyrosine phosphatases associated with the helper T cell phenotype. We further demonstrate that CD22 recognizes a second ligand, CD75, expressed predominantly on activated B cells and shown to be a cell surface alpha 2-6 sialyltransferase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, CD / genetics
  • Antigens, CD / physiology*
  • Antigens, Differentiation, B-Lymphocyte / genetics
  • Antigens, Differentiation, B-Lymphocyte / physiology*
  • Antigens, Differentiation, T-Lymphocyte / physiology
  • B-Lymphocytes / physiology*
  • Base Sequence
  • CD3 Complex
  • Cell Adhesion
  • Cell Adhesion Molecules*
  • Cloning, Molecular
  • DNA / genetics
  • Epitopes
  • Histocompatibility Antigens / physiology*
  • Humans
  • In Vitro Techniques
  • Lectins*
  • Leukocyte Common Antigens
  • Ligands
  • Lymphocyte Activation
  • Molecular Sequence Data
  • Oligonucleotides / chemistry
  • Palatine Tonsil / cytology
  • Receptors, Antigen, T-Cell / physiology
  • Recombinant Fusion Proteins
  • Sialic Acid Binding Ig-like Lectin 2
  • Sialyltransferases / physiology*
  • Structure-Activity Relationship
  • T-Lymphocytes / physiology*
  • beta-D-Galactoside alpha 2-6-Sialyltransferase


  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Differentiation, T-Lymphocyte
  • CD22 protein, human
  • CD3 Complex
  • Cell Adhesion Molecules
  • Epitopes
  • Histocompatibility Antigens
  • Lectins
  • Ligands
  • Oligonucleotides
  • Receptors, Antigen, T-Cell
  • Recombinant Fusion Proteins
  • Sialic Acid Binding Ig-like Lectin 2
  • DNA
  • Sialyltransferases
  • Leukocyte Common Antigens
  • beta-D-Galactoside alpha 2-6-Sialyltransferase