Abstract
In the 1-year double-blind placebo-controlled intervention trial, it was shown that daily supplementation of patients with gastric premalignant lesions (intestinal metaplasia, IM) with a complex, containing Ester-C with antioxidantsand (2100 mg of Ca-ascorbate + 340 mg of bioflavonoids), produced a sharp decrease of abnormally high ornithine decarboxylase activity in IM gastric mucosa that was accom panied by practically total IM regression in 11 of 18 (61%) patients.
Publication types
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Comparative Study
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English Abstract
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Antioxidants / administration & dosage*
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Ascorbic Acid / administration & dosage*
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Chronic Disease
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Double-Blind Method
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Female
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Gastric Mucosa / enzymology
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Gastric Mucosa / microbiology
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Gastric Mucosa / pathology
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Gastritis, Atrophic / diet therapy*
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Gastritis, Atrophic / drug therapy*
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Gastritis, Atrophic / enzymology
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Gastritis, Atrophic / pathology
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Helicobacter Infections / diet therapy*
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Helicobacter Infections / drug therapy*
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Helicobacter Infections / enzymology
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Humans
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Intestines / enzymology
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Intestines / pathology
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Male
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Metaplasia / diet therapy
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Metaplasia / drug therapy
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Metaplasia / enzymology
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Metaplasia / pathology
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Middle Aged
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Ornithine Decarboxylase / metabolism
Substances
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Antioxidants
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Ornithine Decarboxylase
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Ascorbic Acid