Considerations for target validation and industrial approaches

Methods Mol Biol. 2007;361:299-309. doi: 10.1385/1-59745-208-4:299.

Abstract

Target validation in health and disease integrates the modulation of a certain molecular target with an expected biological/biochemical/physiological or pathophysiological response or effect. The current state-of-the-art in target validation requires the interface of multiple complementary approaches and technologies to define the mechanistic connectivity between a molecular target and underlying micro- and macrobiotic processes. Target validation also represents the basis for "drug target validation" with focus on therapeutic applications. The concepts of "target validation" and "drug-based therapeutic intervention" continue to coevolve as new classes of therapeutic agents and delivery systems emerge and enable us to target or modulate previously inaccessible molecular entities.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Design*
  • Drug Evaluation, Preclinical* / instrumentation
  • Drug Evaluation, Preclinical* / methods
  • Proteomics* / instrumentation
  • Proteomics* / methods
  • Technology, Pharmaceutical / instrumentation
  • Technology, Pharmaceutical / methods