Slicer and the argonautes

Nat Chem Biol. 2007 Jan;3(1):36-43. doi: 10.1038/nchembio848.


Though they started out as somewhat mysterious components of the RNAi effector complexes, Argonaute proteins have since taken center stage in RNAi gene silencing. They interact with small RNAs to effect gene silencing in all RNAi-related pathways known so far. We will review the dramatic advances in our understanding of the role of the Argonautes in RNAi through studies of their structure and function.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Models, Molecular
  • Peptide Initiation Factors / chemistry
  • Peptide Initiation Factors / physiology*
  • Protein Structure, Tertiary*
  • Pyrococcus furiosus / chemistry
  • Pyrococcus furiosus / physiology
  • RNA Interference / physiology*
  • RNA Processing, Post-Transcriptional*
  • Ribonuclease III / classification
  • Ribonuclease III / physiology*
  • Schizosaccharomyces pombe Proteins / chemistry
  • Schizosaccharomyces pombe Proteins / physiology
  • Sequence Alignment
  • Signal Transduction


  • Peptide Initiation Factors
  • Schizosaccharomyces pombe Proteins
  • Ribonuclease III