Dosage compensation: the beginning and end of generalization

Nat Rev Genet. 2007 Jan;8(1):47-57. doi: 10.1038/nrg2013.


The genomes of higher eukaryotes are carefully balanced systems of gene expression that compensate for the different numbers of sex chromosomes in the two sexes by adjusting gene expression levels. Different strategies for sex chromosome dosage compensation have evolved, which all involve modulating chromatin structure as a means to fine-tune transcription levels. As data accumulate, previous over-simplifications are being revised, and novel features of the compensation processes are gaining attention, many of which are of sufficient global validity to influence our view on gene expression beyond the realm of dosage compensation itself.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Chromosomal Instability
  • Chromosome Painting
  • Dosage Compensation, Genetic*
  • Drosophila melanogaster / genetics
  • Epigenesis, Genetic
  • Female
  • Gene Expression
  • Humans
  • Male
  • Models, Genetic
  • Sex Chromosomes / genetics
  • X Chromosome Inactivation