Immature teeth with periradicular periodontitis or abscess undergoing apexogenesis: a paradigm shift

J Endod. 2006 Dec;32(12):1205-13. doi: 10.1016/j.joen.2006.07.010. Epub 2006 Oct 13.


Four clinical cases of immature teeth that developed periradicular periodontitis or abscess underwent a conservative treatment approach, i.e. without canal instrumentation. Instead, only copious 2.5% NaOCl irrigation was performed. All cases presented herein developed mature apices after 7 months to 5 years after the initial treatment without complications, although narrowing canal space was observed. Our clinical observations support a shifting paradigm toward a conservative approach by providing a favorable environment for tissue regeneration. The mechanism of this continued development and formation of the root end is discussed.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Dental Pulp / drug effects
  • Dental Pulp / physiopathology
  • Female
  • Humans
  • Male
  • Periapical Abscess / drug therapy
  • Periapical Abscess / physiopathology
  • Periapical Periodontitis / drug therapy*
  • Periapical Periodontitis / physiopathology
  • Regeneration / drug effects
  • Regeneration / physiology
  • Root Canal Irrigants / pharmacology
  • Root Canal Irrigants / therapeutic use*
  • Root Canal Obturation
  • Sodium Hypochlorite / pharmacology
  • Sodium Hypochlorite / therapeutic use*
  • Tooth Apex / growth & development*
  • Tooth Apex / physiopathology


  • Root Canal Irrigants
  • Sodium Hypochlorite