RNA interference: big applause for silencing in Stockholm

Phillip D Zamore

doi:10.1016/j.cell.2006.12.001

RNA interference: big applause for silencing in Stockholm

Cell. 2006 Dec 15;127(6):1083-6. doi: 10.1016/j.cell.2006.12.001.

Author

Phillip D Zamore¹

Affiliation

¹ Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. phillip.zamore@umassmed.edu

PMID: 17174883
DOI: 10.1016/j.cell.2006.12.001

Abstract

Eight years ago, Craig Mello, Andrew Fire, and their coworkers provided the first demonstration that double-stranded RNA (dsRNA) triggers the gene-silencing technique that we now call RNA interference (RNAi). For this landmark discovery, Mello and Fire are honored with this year's Nobel Prize in Physiology or Medicine.

Publication types

Biography
Historical Article
Portrait

MeSH terms

Animals
Caenorhabditis elegans / genetics
History, 20th Century
History, 21st Century
Nobel Prize*
RNA Interference*
RNA, Double-Stranded
RNA, Small Interfering / genetics
United States

Substances

RNA, Double-Stranded
RNA, Small Interfering

Personal name as subject

Craig Mello
Andrew Fire