Abstract
Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. Studies by and now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1alpha.
MeSH terms
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Acetylation
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Administration, Oral
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Aging / metabolism
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Animals
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Diabetes Mellitus, Type 2 / metabolism
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Energy Metabolism
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Glucose / metabolism
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Homeostasis
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Humans
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Insulin / metabolism
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Longevity / drug effects*
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Male
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Mice
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Obesity / metabolism
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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Resveratrol
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Signal Transduction
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Sirtuin 1
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Sirtuins / metabolism*
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Stilbenes / administration & dosage
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Stilbenes / pharmacology*
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Trans-Activators / metabolism*
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Transcription Factors
Substances
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Insulin
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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Ppargc1a protein, mouse
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Stilbenes
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Trans-Activators
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Transcription Factors
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Sirt1 protein, mouse
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Sirtuin 1
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Sirtuins
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Glucose
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Resveratrol