In vino veritas: a tale of two sirt1s?

Cell. 2006 Dec 15;127(6):1091-3. doi: 10.1016/j.cell.2006.11.034.

Abstract

Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. Studies by and now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1alpha.

Publication types

  • Comment

MeSH terms

  • Acetylation
  • Administration, Oral
  • Aging / metabolism
  • Animals
  • Diabetes Mellitus, Type 2 / metabolism
  • Energy Metabolism
  • Glucose / metabolism
  • Homeostasis
  • Humans
  • Insulin / metabolism
  • Longevity / drug effects*
  • Male
  • Mice
  • Obesity / metabolism
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Resveratrol
  • Signal Transduction
  • Sirtuin 1
  • Sirtuins / metabolism*
  • Stilbenes / administration & dosage
  • Stilbenes / pharmacology*
  • Trans-Activators / metabolism*
  • Transcription Factors

Substances

  • Insulin
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Ppargc1a protein, mouse
  • Stilbenes
  • Trans-Activators
  • Transcription Factors
  • Sirt1 protein, mouse
  • Sirtuin 1
  • Sirtuins
  • Glucose
  • Resveratrol