Sensory neurons link the nervous system and autoimmune diabetes

Cell. 2006 Dec 15;127(6):1097-9. doi: 10.1016/j.cell.2006.11.030.


The initial factors that trigger the autoimmune response against pancreatic islets in the nonobese diabetic (NOD) mouse are still unknown. In this issue of Cell, propose that a defect in a subset of sensory neurons innervating the pancreas plays a major role in initiating the chain of events that will lead to local inflammation, islet destruction, and autoimmune diabetes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoimmunity
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Humans
  • Inflammation / physiopathology
  • Islets of Langerhans / immunology
  • Islets of Langerhans / innervation*
  • Mice
  • Mice, Inbred NOD
  • Neurons, Afferent / physiology*
  • Neurosecretory Systems / physiology
  • TRPV Cation Channels / genetics


  • TRPV Cation Channels
  • TRPV1 protein, mouse