A common progenitor at the heart of development

Cell. 2006 Dec 15;127(6):1101-4. doi: 10.1016/j.cell.2006.11.031.


Formation of the heart requires the coordinated functions of cardiac myocytes, smooth muscle cells, endothelial cells, and connective tissue elements. Several recent studies now reveal that these different cell types arise from a common progenitor (). These findings raise interesting questions about the lineage relationships of cardiovascular progenitor cell populations and suggest possibilities for cardiac repair in both congenital and acquired heart disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Lineage*
  • Embryonic Stem Cells / physiology*
  • Heart / embryology*
  • Humans
  • Mesenchymal Stem Cells / physiology
  • Multipotent Stem Cells / physiology*
  • Myocytes, Cardiac / cytology
  • Myocytes, Cardiac / physiology