The lymphopenic mouse in immunology: from patron to pariah

Immunity. 2006 Dec;25(6):851-5. doi: 10.1016/j.immuni.2006.12.002.


A recent surge of interest in the behavior of T and B cells in lymphopenic model systems has resurrected a certain cynicism about the validity of using such models to answer important immunological questions. Here we discuss this skepticism in a broader historical context.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Adoptive Transfer
  • Animals
  • B-Lymphocytes / radiation effects
  • Disease Models, Animal*
  • Lymphopenia*
  • Mice
  • Models, Immunological*
  • T-Lymphocytes / radiation effects