Essentials of local anesthetic pharmacology

Anesth Prog. 2006 Fall;53(3):98-108; quiz 109-10. doi: 10.2344/0003-3006(2006)53[98:EOLAP]2.0.CO;2.


It is impossible to provide effective dental care without the use of local anesthetics. This drug class has an impressive history of safety and efficacy, but all local anesthetics have the potential to produce significant toxicity if used carelessly. The purpose of this review is to update the practitioner on issues regarding the basic pharmacology and clinical use of local anesthetic formulations.

MeSH terms

  • Anesthetics, Local / administration & dosage
  • Anesthetics, Local / adverse effects
  • Anesthetics, Local / chemistry
  • Anesthetics, Local / pharmacology*
  • Carticaine / pharmacology
  • Drug Hypersensitivity
  • Humans
  • Procaine / pharmacology
  • Vasoconstrictor Agents / pharmacology


  • Anesthetics, Local
  • Vasoconstrictor Agents
  • Procaine
  • Carticaine