Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats

Nutr Cancer. 2006;56(1):82-5. doi: 10.1207/s15327914nc5601_11.

Abstract

Gamma (gamma) tocopherol, but not alpha (alpha) tocopherol (vitamin E), has previously been reported as an effective inhibitor of cyclooxygenase (COX) enzyme activity. In a pilot study of 17 rats, mixed tocopherols containing more than 50% gamma-tocopherol, added at 0.1% to an AIN-76A diet, produced a significant inhibition (about 55%) of azoxymethane-induced aberrant crypt foci in the colon of rats. Mixed tocopherols also reduced tetradecanoyl phorbol acetate-induced ear inflammation in mice when topically applied.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Azoxymethane / antagonists & inhibitors
  • Azoxymethane / toxicity
  • Colon / drug effects
  • Colon / pathology
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / prevention & control*
  • Cyclooxygenase Inhibitors / pharmacology*
  • Male
  • Mice
  • Precancerous Conditions / pathology
  • Precancerous Conditions / prevention & control*
  • Random Allocation
  • Rats
  • Rats, Inbred F344
  • Vitamins / pharmacology
  • alpha-Tocopherol / pharmacology*
  • gamma-Tocopherol / pharmacology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase Inhibitors
  • Vitamins
  • gamma-Tocopherol
  • alpha-Tocopherol
  • Azoxymethane