A novel HLA-DRB1*11 allele, DRB1*1155, was found in a patient through routine DRB1 typing using sequence-specific primers (SSP) and confirmed by allele-specific sequence-based typing

K Witter; G Wittmann; A M Lehmeier; T Albert; T Kauke

doi:10.1111/j.1399-0039.2006.00720.x

A novel HLA-DRB111 allele, DRB11155, was found in a patient through routine DRB1 typing using sequence-specific primers (SSP) and confirmed by allele-specific sequence-based typing

Tissue Antigens. 2006 Dec;68(6):531-3. doi: 10.1111/j.1399-0039.2006.00720.x.

Authors

K Witter¹, G Wittmann, A M Lehmeier, T Albert, T Kauke

Affiliation

¹ Labor für Immungenetik, University Munich, Munich, Germany. klaus.witter@med.uni-muenchen.de

PMID: 17176450
DOI: 10.1111/j.1399-0039.2006.00720.x

Abstract

In comparison with DRB1*1155 allele, DRB1*1103 differs at position 220/221, 'GC' is changed to 'CT', or DRB1*1125 differs at position 210/211, 'AG' is substituted with 'GA'. This results in a single amino acid exchange depending on the closest related allele investigated, whether DRB*1103 codon 74 alanine (GCG) is changed to leucine (CTG) or DRB1*1125 codon 71 arginine (GAG) is replaced with glutamic acid.

MeSH terms

Alleles*
Base Sequence
DNA Primers
Female
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Analysis, DNA

Substances

DNA Primers
HLA-DR Antigens
HLA-DRB1 Chains
HLA-DRB1*11:55 antigen

Associated data

GENBANK/AM231063