A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1

Nutr Neurosci. 2006 Jun-Aug;9(3-4):169-78. doi: 10.1080/110284150600955164.


We investigated the components of ginger that are involved in increasing body temperature. Gingerols ([6,8,10]-gingerols) and shogaols ([6,8,10]-shogaols) having different alkyl carbon chain lengths were targeted. All the gingerols and shogaols increased intracellular calcium concentration in rat transient receptor potential vanilloid subtype 1 (TRPV1)-expressing HEK293 cells via TRPV1. In this regard, the shogaols were more potent than the gingerols. Aversive responses were induced by [6]-, [10]-gingerol, and [6]-shogaol (5 mmol/l) in rats when these compounds were applied to the eye; however, no response was observed in response to [10]-shogaol (5 and 10 mmol/l). [10]-Shogaol induced nociceptive responses via TRPV1 in rats following its subcutaneous injection into the hindpaw; the pungent compound capsaicin (CAP) and [6]-shogaol were observed to have similar effects. Moreover, adrenal catecholamine secretion, which influences energy consumption, was promoted in rats in response to [6]- and [10]-gingerols and [6]- and [10]-shogaols (1.6 micromol/kg, i.v.). [10]-Shogaol-induced adrenaline secretion was inhibited by administration of capsazepine, a TRPV1 antagonist. In conclusion, gingerols and shogaols activated TRPV1 and increased adrenaline secretion. Interestingly, [10]-shogaol is the only nonpungent compound among the gingerols and shogaols, suggesting its usefulness as a functional ingredient in food.

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium Channels / drug effects
  • Calcium Channels / physiology*
  • Capsaicin / pharmacology
  • Catechols / pharmacology*
  • Cell Line
  • Cooking
  • Epinephrine / metabolism*
  • Ginger*
  • Humans
  • Kidney
  • Kinetics
  • Male
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • TRPV Cation Channels / drug effects
  • TRPV Cation Channels / physiology*


  • Calcium Channels
  • Catechols
  • Plant Extracts
  • TRPV Cation Channels
  • TRPV6 channel
  • TRPV6 protein, human
  • shogaol
  • Capsaicin
  • Calcium
  • Epinephrine