Effect of Aerva lanata on calcium oxalate urolithiasis in rats

Indian J Exp Biol. 2006 Dec;44(12):981-6.


Calcium oxalate (CaOx) stone was induced in rats using 0.75% of ethylene glycol in drinking water for 28 days. Ethylene glycol treated rats showed significant increase in the activities of oxalate synthesizing enzymes such as glycolic acid oxidase (GAO) in liver and lactate dehydrogenase (LDH) in liver and kidney. CaOx crystal deposition, as indicated by increased excretion of stone-forming constituents in urine, such as calcium, oxalate, uric acid, phosphorus and protein and decreased concentration of inhibitors, such as citrate and magnesium was observed in ethylene glycol induced urolithic rats. Histopathological studies also confirmed the deposition of CaOx crystals. Administration of Aerva lanata aqueous suspension (2g/kg body wt/dose/day for 28 days) to CaOx urolithic rats had reduced the oxalate synthesizing enzymes, diminished the markers of crystal deposition in the kidney. The results of the present study confirmed that A. lanata can be used as an curative agent for urolithiasis.

MeSH terms

  • Alcohol Oxidoreductases / metabolism
  • Amaranthaceae / chemistry*
  • Analysis of Variance
  • Animals
  • Calcium Oxalate / metabolism*
  • L-Lactate Dehydrogenase / metabolism
  • Male
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Wistar
  • Urolithiasis / drug therapy*
  • Urolithiasis / enzymology
  • Urolithiasis / metabolism


  • Plant Extracts
  • Calcium Oxalate
  • Alcohol Oxidoreductases
  • L-Lactate Dehydrogenase
  • glycollate oxidase