A rare case of choroidal metastasis presented after conservative management of endometrial cancer

Int J Gynecol Cancer. Nov-Dec 2006;16(6):2044-8. doi: 10.1111/j.1525-1438.2006.00730.x.

Abstract

Hematogenous dissemination from endometrial cancer is quite rare. We report a 31-year-old woman who developed choroidal metastasis following conservative management of early-stage endometrial carcinoma. She had received kidney transplantation and was taking steroids and cyclosporine. Three years after hysterectomy for persistent endometrial carcinoma, she developed multiple metastatic disease (to both lungs and right pelvis), and while on treatment with paclitaxel and carboplatin, she complained of a rapid visual deterioration. Ophthalmologic evaluation revealed a metastatic choroidal tumor associated with multiple central nervous system metastases. The patient refused further treatment and died 1 month after diagnosis of choroidal involvement. In conclusion, this is the first reported case of choroidal metastasis from endometrial cancer and highlights the need to consider immunosuppressive treatment as an absolute contraindication to conservative fertility-sparing treatment in gynecological malignancies.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Choroid Neoplasms / blood supply
  • Choroid Neoplasms / diagnostic imaging
  • Choroid Neoplasms / pathology*
  • Choroid Neoplasms / secondary*
  • Endometrial Neoplasms / classification
  • Endometrial Neoplasms / drug therapy*
  • Endometrial Neoplasms / pathology*
  • Endometrial Neoplasms / surgery
  • Female
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / secondary
  • Prednisone / therapeutic use
  • Radiography
  • Ultrasonography

Substances

  • Prednisone