Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

Clin Exp Immunol. 2007 Jan;147(1):155-63. doi: 10.1111/j.1365-2249.2006.03257.x.

Abstract

The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / immunology*
  • Antigens, Differentiation / immunology*
  • Antineoplastic Agents / pharmacology*
  • B-Lymphocytes / drug effects
  • B7-1 Antigen / immunology
  • CD28 Antigens / immunology
  • CD4-Positive T-Lymphocytes / immunology
  • CD40 Antigens / immunology
  • CTLA-4 Antigen
  • Cell Proliferation / drug effects
  • Cell Survival
  • Cells, Cultured
  • Concanavalin A
  • Curcumin / pharmacology*
  • Flow Cytometry
  • Immunoglobulin G / immunology
  • Lipopolysaccharides
  • Lymphocytes / immunology*
  • Macrophage Activation / drug effects
  • Macrophages / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Resveratrol
  • Stilbenes / pharmacology*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Antineoplastic Agents
  • B7-1 Antigen
  • CD28 Antigens
  • CD40 Antigens
  • CTLA-4 Antigen
  • Ctla4 protein, mouse
  • Immunoglobulin G
  • Lipopolysaccharides
  • Stilbenes
  • Concanavalin A
  • Curcumin
  • Resveratrol