Isolation and characterisation of a phenolic impurity in a commercial sample of duloxetine

J Pharm Biomed Anal. 2007 Mar 12;43(4):1573-5. doi: 10.1016/j.jpba.2006.11.026. Epub 2006 Dec 18.

Abstract

A phenolic impurity of duloxetine hydrochloride was isolated and characterised (MS, NMR, X-ray-analysis).

MeSH terms

  • Drug Contamination
  • Duloxetine Hydrochloride
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry / methods
  • Molecular Structure
  • Phenol / analysis
  • Phenol / chemistry
  • Phenol / isolation & purification*
  • Selective Serotonin Reuptake Inhibitors / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Thiophenes / chemistry*

Substances

  • Serotonin Uptake Inhibitors
  • Thiophenes
  • Phenol
  • Duloxetine Hydrochloride