The multifaceted role of Notch in cancer

Curr Opin Genet Dev. 2007 Feb;17(1):52-9. doi: 10.1016/j.gde.2006.12.001. Epub 2006 Dec 18.


The diverse roles that Notch signals play during the development and maintenance of normal tissues are recapitulated in different forms of cancer. Depending on the tumor type, Notch can variously promote or limit tumor growth through either cell autonomous or cell non-autonomous effects on differentiation, cellular metabolism, cell cycle progression, angiogenesis, and possibly self-renewal and immune function. Of particular interest, recent findings indicate that a high fraction of T-cell acute lymphoblastic leukemias and lymphomas have activating mutations in the Notch 1 receptor, and that Notch signaling might have a role in the maintenance of normal and malignant stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Genes, Tumor Suppressor
  • Humans
  • Models, Biological
  • Mutation / genetics
  • Neoplasms / genetics*
  • Neoplasms / physiopathology
  • Oncogenes / genetics*
  • Protein Structure, Tertiary
  • Receptors, Notch / genetics*
  • Signal Transduction / genetics*


  • Receptors, Notch