c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection

Infect Immun. 2007 Mar;75(3):1520-3. doi: 10.1128/IAI.01316-06. Epub 2006 Dec 18.


c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-kappaB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.

MeSH terms

  • Animals
  • Genetic Predisposition to Disease*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Proto-Oncogene Proteins c-fos / deficiency*
  • Proto-Oncogene Proteins c-fos / genetics*
  • Salmonella Infections / immunology*
  • Salmonella Infections / microbiology
  • Salmonella typhimurium* / immunology


  • Proto-Oncogene Proteins c-fos