Successful treatment of myelodysplastic syndrome-induced pyoderma gangrenosum

Neth J Med. 2006 Dec;64(11):422-4.


We report successful treatment of a refractory myelodysplastic syndrome-associated pyoderma gangrenosum with the combination of thalidomide and interferon-alpha2a in a single patient. A non-healing wound developed on a 40-year-old woman's left thumb after minor trauma. Massive ulcerovegetative lesions developed after reconstruction surgery. Histopathological examination of the bone marrow and cytogenetic studies revealed an atypical myeloproliferative/myelodysplastic syndrome. The skin lesions resolved dramatically after two months of thalidomide and interferon-alpha2a combination therapy and the haematological status improved.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Drug Therapy, Combination
  • Female
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage*
  • Myelodysplastic Syndromes / complications*
  • Myelodysplastic Syndromes / drug therapy
  • Pyoderma Gangrenosum / drug therapy*
  • Pyoderma Gangrenosum / etiology*
  • Recombinant Proteins
  • Thalidomide / administration & dosage*
  • Treatment Outcome


  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Thalidomide