Sensitivity of rabies virus to type I interferon is determined by the phosphoprotein gene

Microbiol Immunol. 2006;50(12):975-8. doi: 10.1111/j.1348-0421.2006.tb03875.x.


The growth of a virulent strain of fixed rabies virus, Nishigahara, in mouse neuroblastoma NA cells treated with type I interferon (IFN) was compared with that of a derivative avirulent strain, Ni-CE. Nishigahara strain was slightly sensitive to IFN treatment but still grew more efficiently than did Ni-CE strain in IFN-treated NA cells. Furthermore, a virulent chimeric virus with the phosphoprotein gene from Nishigahara strain in the Ni-CE genome was less sensitive to IFN treatment than was Ni-CE strain, indicating that the IFN sensitivity is determined by the phosphoprotein gene of the virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Resistance, Viral / physiology*
  • Interferon Type I / pharmacology*
  • Mice
  • Molecular Chaperones
  • Phosphoproteins / genetics
  • Phosphoproteins / physiology*
  • Rabies / virology*
  • Rabies virus / drug effects*
  • Rabies virus / genetics
  • Rabies virus / pathogenicity
  • Viral Structural Proteins / genetics
  • Viral Structural Proteins / physiology*
  • Virulence / genetics


  • Interferon Type I
  • Molecular Chaperones
  • P phosphoprotein, Rabies virus
  • Phosphoproteins
  • Viral Structural Proteins