The effects of intravaginal clindamycin and metronidazole therapy on vaginal mobiluncus morphotypes in patients with bacterial vaginosis

Sex Transm Dis. 2007 Apr;34(4):197-202. doi: 10.1097/01.olq.0000235152.98601.d7.


Objective: The objective of this study was to compare the effects of treatments for bacterial vaginosis (BV) on vaginal Mobiluncus morphotypes.

Study design: Analyses were performed on Mobiluncus scores from similarly conducted studies evaluating clindamycin vaginal single-dose cream (CVSDC) or metronidazole vaginal gel (MVG) in 55 patients with BV and with Mobiluncus morphotypes at baseline.

Results: Both treatment groups demonstrated significant reductions in Mobiluncus score. However, the Mobiluncus score at test-of-cure was lower in the CVSDC than in the MVG group (P=0.0471). More patients in the CVSDC group than in the MVG group achieved microbiologic (57.5% vs. 26.7%; P=0.04), clinical (57.5% vs. 26.7%; P=0.04), and therapeutic cures of BV (45.0% vs. 20.0%; P=0.09).

Conclusion: Clindamycin reduces vaginal Mobiluncus morphotypes to a greater extent than metronidazole in patients with BV; this correlates with a higher BV cure rate.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Actinomycetales Infections / drug therapy*
  • Actinomycetales Infections / microbiology
  • Actinomycetales Infections / pathology
  • Administration, Intravaginal
  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / pharmacology
  • Clindamycin / administration & dosage*
  • Clindamycin / pharmacology
  • Female
  • Humans
  • Metronidazole / administration & dosage*
  • Metronidazole / pharmacology
  • Mobiluncus / classification
  • Mobiluncus / drug effects*
  • Retrospective Studies
  • Self Care
  • Treatment Outcome
  • Vaginosis, Bacterial / drug therapy*
  • Vaginosis, Bacterial / microbiology
  • Vaginosis, Bacterial / pathology


  • Anti-Bacterial Agents
  • Metronidazole
  • Clindamycin