The Potential Role of Podoplanin in Tumour Invasion

Br J Cancer. 2007 Jan 15;96(1):1-5. doi: 10.1038/sj.bjc.6603518. Epub 2006 Dec 19.

Abstract

Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Cell Movement
  • Cytoskeleton / metabolism
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / metabolism*
  • Mice
  • Neoplasm Invasiveness / pathology
  • Neoplasm Invasiveness / physiopathology*
  • Neoplasms / diagnosis
  • Neoplasms / genetics*
  • Neoplasms / therapy

Substances

  • Actins
  • Biomarkers, Tumor
  • Gp38 protein, mouse
  • Membrane Glycoproteins
  • PDPN protein, human