Activation of apoptosis pathways by granzyme B

Cell Death Differ. 1996 Jul;3(3):269-74.


Cytotoxic lymphocytes induce apoptosis of target cells by degranulating and releasing the serine protease granzyme B and the pore forming protein perforin. Granzyme B is an aspartic acid protease similar to members of the interleukin 1beta converting enzyme (ICE) family. We review the evidence for the participation members of the ICE family of proteases and cdc2 kinase in granzyme B-induced apoptosis.