Can the peroxosuccinate complex in the catalytic cycle of taurine/alpha-ketoglutarate dioxygenase (TauD) act as an alternative oxidant?

Chem Commun (Camb). 2007 Jan 14:(2):171-3. doi: 10.1039/b611273k. Epub 2006 Oct 23.

Abstract

Density functional theoretical studies on the catalytic properties of the peroxosuccinate intermediate in the catalytic cycle of taurine/alpha-ketoglutarate dioxygenase suggest that it cannot act as a second oxidant.

MeSH terms

  • Alkenes / chemistry
  • Catalysis
  • Catalytic Domain
  • Epoxy Compounds / chemistry
  • Hydroxylation
  • Iron / chemistry
  • Mixed Function Oxygenases / chemistry*
  • Models, Chemical
  • Molecular Structure
  • Oxidants / chemistry*
  • Oxidation-Reduction
  • Oxygen / chemistry
  • Peroxides / chemistry*
  • Succinic Acid / chemistry*
  • Thermodynamics

Substances

  • Alkenes
  • Epoxy Compounds
  • Oxidants
  • Peroxides
  • Succinic Acid
  • propylene
  • Iron
  • Mixed Function Oxygenases
  • taurine-alpha-ketoglutarate dioxygenase
  • Oxygen