[The ultrastructure of fibrous and histiocytic skin tumors (dermatofibroma, dermatofibrosarcoma protuberans, fibroxanthoma, and histiocytoma) (author's transl)]

Virchows Arch A Pathol Anat Histol. 1975 Oct 30;368(3):253-74. doi: 10.1007/BF00432527.
[Article in German]


A report on the ultrastructure of the following skin tumors: dermatofibroma (7 cases), histiocytoma (4 cases), dermatofibrosarcoma protuberans (1 case), and fibroxanthoma (1 case). Because of their different ultrastructural characteristics a division into two groups is possible: one group of tumors would include dermatofibroma, dermatofibrosarcoma protuberans, and fibroxanthoma, where the formation of fibers is extensive and fibroblasts are suggested for its histogenesis. These types of tumor differ from histiocytoma, the cellular character of which is determined by a very pronounced phagocytosis and storage of lipid and hemosiderin; a histogenesis from histiocytes is probable. The nuclei of dermatofibroma and histiocytoma show a simple surfacedevelopment, whereas the nuclei of dermatofibrosarcoma protuberans and fibroxanthoma show multisegmented nuclei ("labyrinth nuclei"). In the case of dermatofibrosarcoma protuberans this kind of nuclear segmentation seems to be a morphologic correlate of its semimalignancy. Based on ultrastructural analysis a classification of these fiber-producing tumors into "fibrous histiocytomas" is not justified.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cell Nucleolus / ultrastructure
  • Cell Nucleus / ultrastructure
  • Cytoplasm / ultrastructure
  • Endoplasmic Reticulum / ultrastructure
  • Female
  • Fibroma / pathology*
  • Fibrosarcoma / pathology*
  • Golgi Apparatus / ultrastructure
  • Histiocytoma, Benign Fibrous / pathology*
  • Humans
  • Lymphocytes / ultrastructure
  • Male
  • Middle Aged
  • Mitochondria / ultrastructure
  • Organoids / ultrastructure
  • Ribosomes / ultrastructure
  • Skin Neoplasms / pathology*