Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition study

Kidney Int. 2007 Feb;71(3):239-44. doi: 10.1038/ Epub 2006 Dec 20.


Inflammatory markers are elevated in persons with estimated glomerular filtration rates less than 60 ml/min/1.73 m2. As cystatin C may detect small changes in kidney function not detected by estimated glomerular filtration rate, we evaluated the association between cystatin C and serum markers of inflammation in older adults with estimated glomerular filtration rate >or=60. This is an analysis using measures from the Health, Aging, and Body Composition Study, a cohort of well-functioning adults aged 70-79 years. Cystatin C correlated with all five inflammatory biomarkers: C-reactive protein (r=0.08), interleukin-6 (r=0.19), tumor necrosis factor alpha (TNF-alpha) (r=0.41), soluble TNF receptor 1 (STNF-R1) (r=0.61), and soluble TNF receptor 2 (STNF-R2) (r=0.54); P<0.0005 for all. In adjusted analyses, cystatin C concentrations appeared to have stronger associations with each biomarker compared with estimated glomerular filtration rate or serum creatinine. Participants with a cystatin C>or=1.0 mg/l had significantly higher levels of all five biomarkers compared to those with a cystatin C<1.0 (mean differences ranging 16-29%, all P<0.05). Cystatin C has a linear association with inflammatory biomarkers in an ambulatory elderly cohort with estimated glomerular filtration rates >or=60; associations are particularly strong with TNF-alpha and the STNF-R.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aging / blood
  • Aging / physiology*
  • Biomarkers / blood
  • Body Composition
  • C-Reactive Protein / analysis
  • Cohort Studies
  • Cystatin C
  • Cystatins / blood*
  • Female
  • Glomerular Filtration Rate / physiology*
  • Health
  • Humans
  • Inflammation / blood
  • Inflammation / diagnosis
  • Interleukin-6 / blood
  • Kidney / physiology*
  • Kidney Diseases / blood
  • Kidney Diseases / diagnosis*
  • Male
  • Receptors, Tumor Necrosis Factor, Type II / blood
  • Tumor Necrosis Factor-alpha / blood


  • Biomarkers
  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Interleukin-6
  • Receptors, Tumor Necrosis Factor, Type II
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein