Microbial Ecology: Human Gut Microbes Associated With Obesity

Nature. 2006 Dec 21;444(7122):1022-3. doi: 10.1038/4441022a.

Abstract

Two groups of beneficial bacteria are dominant in the human gut, the Bacteroidetes and the Firmicutes. Here we show that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet. Our findings indicate that obesity has a microbial component, which might have potential therapeutic implications.

Publication types

  • Clinical Trial

MeSH terms

  • Adiposity / drug effects
  • Adiposity / physiology
  • Animals
  • Bacteria / classification
  • Bacteria / genetics
  • Bacteria / isolation & purification*
  • Bacteroidetes / classification
  • Bacteroidetes / genetics
  • Bacteroidetes / isolation & purification
  • Diet*
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Obesity / microbiology*
  • RNA, Ribosomal, 16S / genetics

Substances

  • RNA, Ribosomal, 16S