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Review
, 8 (1), 49-62

Integrating Cell-Signalling Pathways With NF-kappaB and IKK Function

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Review

Integrating Cell-Signalling Pathways With NF-kappaB and IKK Function

Neil D Perkins. Nat Rev Mol Cell Biol.

Abstract

Nuclear factor (NF)-kappaB and inhibitor of NF-kappaB kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-kappaB or IKK function contributes to many human diseases, including cancer. However, the NF-kappaB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate.

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