Integrating Cell-Signalling Pathways With NF-kappaB and IKK Function

Nat Rev Mol Cell Biol. 2007 Jan;8(1):49-62. doi: 10.1038/nrm2083.

Abstract

Nuclear factor (NF)-kappaB and inhibitor of NF-kappaB kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-kappaB or IKK function contributes to many human diseases, including cancer. However, the NF-kappaB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Enzyme Activation
  • Humans
  • I-kappa B Kinase / metabolism*
  • I-kappa B Proteins / metabolism
  • NF-kappa B / metabolism*
  • Protein Subunits / metabolism
  • Signal Transduction*

Substances

  • I-kappa B Proteins
  • NF-kappa B
  • Protein Subunits
  • I-kappa B Kinase