Anti-adhesive molecules of the extracellular matrix

Curr Opin Cell Biol. 1991 Oct;3(5):800-4. doi: 10.1016/0955-0674(91)90053-2.


The prototype extracellular matrix glycoproteins had been identified on the basis of their activity in promoting cell adhesion and spreading. Recently, more and more evidence is accumulating that the reverse effect of extracellular matrix proteins, namely the inhibition of cell adhesion and spreading, may be equally important for proper cell function during morphogenesis and development. Several anti-adhesive proteins have been described and their mechanisms of action are being investigated.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Adhesion Molecules, Neuronal / physiology*
  • Cell Adhesion*
  • Extracellular Matrix / physiology*
  • Extracellular Matrix Proteins / physiology*
  • Glycoproteins / metabolism
  • Molecular Sequence Data
  • Osteonectin / physiology*
  • Tenascin


  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Glycoproteins
  • Osteonectin
  • Tenascin